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uses pig islets to replace human islets that have been destroyed by type 1 diabetes.

Type 1 diabetes

Type 1 diabetes arises from the failure of the pancreas to produce insulin, the hormone required to control glucose uptake by cells in the body. It results from the body destroying its own islets, the insulin producing cells in the pancreas. The disease generally develops during childhood and is also referred to as juvenile diabetes or insulin dependent diabetes mellitus. Type 1 diabetes usually requires life-long treatment with regular insulin injections.

There are currently approximately 8 million adults and 3 million children with type 1 diabetes worldwide.

Around 5-15% of people with type 1 diabetes (540,000-1,600,000 people worldwide) are extremely sensitive to insulin therapy and lack hormone counter-regulator measures. This means they suffer from recurrent serious hypoglycaemia or low blood glucose levels. People who don’t get warning symptoms (sweating, tremor and tachycardia) during hypoglycaemia episodes can develop dizziness, confusion and blurred vision. In severe cases, uncontrolled hypoglycaemia can lead to coma, seizure, or even death.

Fear of recurrent hypoglycaemia decreases quality of life and can also affect treatment adherence and prevent good glycaemic control. The long-term complications of chronically elevated blood glucose levels include retinal damage and blindness, kidney damage and renal failure, heart disease, stroke, nerve damage and foot ulcers and amputation.


In clinical trials performed to date, DIABECELL has shown the potential to significantly reduce the number of unaware hypoglycaemic events that people living with type I diabetes experience. At the same time, these people have been able to reduce their insulin dose without experiencing a rise in HbA1c.


DOL is now preparing for a larger Phase II/III study to more fully determine the frequency and extent of this benefit.



Diabetes New Zealand


Australian Diabetes Society

Diabetes Australia

International Diabetes Federation

International Diabetes Institute

Juvenile Diabetes Foundation Australia (JDFA)

Juvenile Diabetes Research Foundation (JDRF)

The Islet Foundation

Children with Diabetes Foundation

Centers for Disease Control and Prevention

World Health Organization

National Diabetes Information Clearinghouse